Pathogens, in particular malaria parasites, must interact with the host for survival. We aim to uncover and exploit these interactions to prevent disease.Learn more
Antibodies play key roles in protection against infectious disease. We aim to determine the mechanisms of productive antibody neutralization of parasites and bacteria.Learn more
Producing antigens that focus the immune response to protective epitopes is critical for future vaccines. We aim to design and engineer novel antigens that will lead to protection.Learn more
Pathogens have acquired various methods to resist available drugs and therapies. We aim to define drug resistance to aid in the arms race against drug resistant pathogens.Learn more
The Tolia Laboratory study the pathogenesis of infectious disease from atom to host-pathogen interaction
We use the tools of structural biology, biochemistry, biophysics, and microbiology to examine proteins and protein complexes associated with pathogenesis.
One major focus is to define the molecular mechanisms required for the pathogenesis of malaria. Malaria affects half the world's population, leads to 300-500 million cases per year, and results in approxiamately 1 million deaths annually. A majority of fatalities are in children under the age of five.
A second major focus is to define the mechanisms of bacterial drug resistance to available antibiotics. Drug resistance has emerged as a major global threat to the control of previously routine infections.
Postdoctoral positions now available
Postdoctoral positions are immediately available to study the structural basis for host-pathogen interactions, structural vaccinology, and the mechanisms of drug resistance.See details
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Media Coverage: WUSTL News
Our mission and vision
To uncover fundamental phenomena that drive the pathogenesis of infectious diseases and apply this knowledge to enable the next generation of the drugs, vaccines, therapeutics and diagnostics.
To address diseases of global importance particularly those that are neglected and that do not receive adequate scientific attention.