For an up to date list from Pubmed please click:

PDFs available upon request by emailing tolia@wustl.edu.

# co-first author, * co-senior author

Armiyaw S. Nasamu, Svetlana Glushakova, Ilaria Russo, Barbara Vaupel, Anna Oksman, Arthur S. Kim, Daved H. Fremont, , Josh R. Beck, Marvin J. Meyers, Jacquin C. Niles, Joshua Zimmerberg, Daniel E. Goldberg , "Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion" Science (2017) Oct 27;358(6362):518-522.

Rachel L. Kinsell, Juvenal Lopez, Lauren D. Palmer, Nichole D. Salinas, Eric P. Skaar, , Mario F. Feldman, "Defining the interaction of the protease CpaA with its type II secretion-chaperone CpaB and its contribution to virulence in Acinetobacter species " Journal of Biological Chemistry (2017) Oct 5. pii: jbc.M117.808394.

Yining Huang, Nichole D. Salinas, Edwin Chen, , Michael L. Gross, "Native Mass Spectrometry, Ion mobility, and Collision-Induced Unfolding Categorize Malaria Antigen/Antibody Binding" Journal of the American Society for Mass Spectrometry (2017) https://doi.org/10.1007/s13361-017-1782-0

Elina Ovchynnikova#, Francesca Aglialoro#, Arthur E. H. Bentlage, Gestur Vidarsson, Nichole D. Salinas, Marieke von Lindern, *, Emile van den Akker*, "DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism." Blood (2017) Jul 28. pii: blood-2017-03-774364. doi: 10.1182/blood-2017-03-774364.

John R. Jimah, Paul H. Schlesinger, , "Liposome Disruption Assay to Examine Lytic Properties of Biomolecules." Bio-protocol (2017) 7(15): e2433. DOI: 10.21769/BioProtoc.2433

John R. Jimah, Paul H. Schlesinger, , "Membrane Lipid Screen to Identify Molecular Targets of Biomolecules," Bio-protocol (2017) 7(15): e2427. DOI: 10.21769/BioProtoc.2427

Jooyoung Park#, Andrew J Gasparrini#, Margaret R Reck, Chanez T Symister, Jennifer L Elliott, Joseph P Vogel, Timothy A Wencewicz*, Gautam Dantas*, *, "Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes." Nature Chemical Biology (2017) Jul;13(7):730-736. doi: 10.1038/nchembio.2376.

Marion Koch, Katherine E. Wright, Oliver Otto, Maik Herbig, Nichole D. Salinas, , Timothy J. Satchwell, Jochen Guck, Nicholas J. Brookse, and Jake Bauma, "Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion." Proceedings of the National Academy of Sciences USA (2017) Apr 18;114(16):4225-4230. doi: 10.1073/pnas.1620843114.

Xavier Sisquella, Thomas Nebl, Jennifer K Thompson, Lachlan Whitehead, Brian M Malpede, Nichole D Salinas, Kelly Rogers, , Andrea Fleig, Joseph O’Neill, Wai-Hong Tham, F David Horgen, Alan F Cowman, "Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion." eLife (2017) Feb 22;6. pii: e21083. doi: 10.7554/eLife.21083.

Vasilios Kalas, Jerome S. Pinkner, Thomas J. Hannan, Michael E. Hibbing, Karen W. Dodson, Alex S. Holehouse, Hao Zhang, , Michael L. Gross, Rohit V. Pappu, James Janetka, and Scott J. Hultgren, "Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions." Science Advances (2017) Feb; 3(2): e1601944

John Jimah, Nichole D Salinas, Monica Sala-Rabanal, Nathaniel G Jones, L David Sibley, Colin G Nichols, Paul H Schlesinger, , "Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption." eLife (2016) Dec 1;5. pii: e20621. doi: 10.7554/eLife.20621.

Kathryn E Price, Christopher M Armstrong, Leah S Imlay, Dana M Hodge, C Pidathala, Natalie J Roberts, Jooyoung Park, Marwa Mikati, Raman Sharma, Alexandre S Lawrenson, , Neil G Berry, Paul M O’Neill, Audrey R Odom John, "Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD." Scientific Reports (2016) Nov 18;6:36777. doi: 10.1038/srep36777

Edwin Chen, Nichole D Salinas, Yining Huang, Francis B Ntumngia, Manolo D. Plascencia, Michael L. Gross, John H Adams, , "Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein." Proceedings of the National Academy of Sciences USA (2016) May 31;113(22):6277-82. doi: 10.1073/pnas.1600488113.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, , Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P, "Data publication with the structural biology data grid supports live analysis." Nature Communications (2016) Mar 7;7:10882. doi: 10.1038/ncomms10882.
Nichole D Salinas, , "Red cell receptors as access points for malaria infection." Current Opinion in Hematology (2016) Jan 13. [Epub ahead of print]
Jooyoung Park#, Ann M Guggisberg#, Audrey R Odom*, , "Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1." Acta Crystallographica Section D (2015) Sep;71(Pt 9):1824-34. doi: 10.1107/S1399004715012067.
Michael S Behnke, Asis Khan , Elvin J Lauron, John R Jimah, Qiuling Wang, , L David Sibley, "Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii." PLOS Genetics (2015) Aug 20;11(8):e1005434. doi: 10.1371/journal.pgen.1005434

Edwin Chen, Nichole D Salinas, Francis B Ntumngia, John H Adams, , "Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design." PLOS Neglected Tropical Diseases (2015) Mar 20;9(3):e0003644. doi: 10.1371/journal.pntd.0003644.

Xiao L Xu, Shawei Chen, Nichole D Salinas, , Gregory A. Grant "Comparison of Type 1 D-3-Phosphoglycerate Dehydrogenases Reveals Unique Regulation in Pathogenic Mycobacteria." Archives of Biochemistry and Biophysics (2015) Feb 16. pii: S0003-9861(15)00070-3. doi: 10.1016/j.abb.2015.02.008. [Epub ahead of print]

Joshua Muia, Jian Zhu, Garima Gupta, Sandra L. Haberichter, Kenneth D. Friedman, Hendrik B. Feys, Louis Deforche, Karen Vanhoorelbeke, Lisa A. Westfield, Robyn Roth, , John E. Heuser, J. Evan Sadler. "Allosteric activation of ADAMTS13 by von Willebrand factor." Proceedings of the National Academy of Sciences USA (2014) Dec 15. pii: 201413282. [Epub ahead of print]

Nichole D Salinas#, May M Paing#, . "Critical glycosylated residues in exon three of erythrocyte glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity." mBio (2014) 5(5):01606-14. doi:10.1128/mBio.01606-14.
Ann M Guggisberg#, Jooyoung Park#, Rachel L Edwards, Megan L Kelly, Dana M Hodge, *, Audrey R Odom*. "A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites." Nature Communications (2014) 5:4467. doi: 10.1038/ncomms5467 Media Coverage: WUSTL News
May M Paing, . "Multimeric Assembly of Host-Pathogen Adhesion Complexes Involved in Apicomplexan Invasion" PLOS Pathogens (2014) 10(6): e1004120. doi:10.1371/journal.ppat.1004120
Brian M Malpede, . "Malaria Adhesins: Structure and Function." Cellular Microbiology (2014) May;16(5):621-31. doi: 10.1111/cmi.12276.

Joseph D Batchelor, Brian M Malpede, Natalie S Omattage, Gregory T DeKoster, Katherine A Henzler-Wildman, . "Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC." PLOS Pathogens (2014) 10(1): e1003869. doi:10.1371/journal.ppat.1003869
Media Coverage: The Times of India Science Daily Eurekalert WUSTL News

Nichole D Salinas, . "A quantitative assay for binding and inhibition of Plasmodium falciparum Erythrocyte Binding Antigen 175 reveals high affinity binding depends on both DBL domains." Protein Expression and Purification (2014) pii: S1046-5928(13)00277-5. doi: 10.1016/j.pep.2013.12.008.

Aida S. Badiane, Amy K. Bei, Ambroise D. Ahouidi, Saurabh D. Patel, Nichole Salinas, Daouda Ndiaye, Ousmane Sarr, Omar Ndir, , Souleymane Mboup, and Manoj T. Duraisingh. "Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of erythrocyte invasion pathway." Clinincal Vaccine Immunology (2013) 20(8):1238-45. doi: 10.1128/CVI.00135-13. Epub 2013 Jun 12.

Edwin Chen, May M. Paing, Nichole Salinas, B. Kim Lee Sim, . "Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175." PLOS Pathogens (2013) 9(5): e1003390. doi:10.1371/journal.ppat.1003390

Brian M Malpede, Daniel H Lin, . "Molecular Basis for Sialic Acid-dependent Receptor Recognition by Plasmodium falciparum Erythrocyte Binding Antigen 140/BAEBL." Journal of Biological Chemistry (2013) Apr 26;288(17):12406-15. Epub Mar 18.

Daniel H Lin, Brian M Malpede, Joseph D Batchelor, . "Crystal and Solution Structures of Plasmodium falciparum Erythrocyte Binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion." Journal of Biological Chemistry (2012) Oct 26;287(44):36830-6. Epub Sep 18.

Joseph D Batchelor, Jacob A Zahm, . "Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC." Nature Structural & Molecular Biology (2011) Jul 10;18(8):908-14

, Eric J Enemark, B Kim Lee Sim, Leemor Joshua-Tor. "Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite P. falciparum." Cell (2005) Jul 29; 122(2):183-93

, Leemor Joshua-Tor. "Slicer and the Argonautes" Nature Chemical Biology (2007) Jan;3(1):36-43.

Erbay Yigit, Pedro J. Batista, Yanxia Bei, Ka Ming Pang, Chun-Chieh G. Chen, , Leemor Joshua-Tor, Shohei Mitani, Martin J. Simard, Craig C Mello. "Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi" Cell (2006) Nov 17;127(4):747-757.

Danielle V Irvine#, Mikel Zaratiegui#, #, Derek B Goto, Daniel H Chitwood, Matthew W Vaughn, Leemor Joshua-Tor, Robert A Martienssen "Argonaute slicing is required for heterochromatic silencing and spreading." Science (2006) Aug 25; 313(5790):1134-7.

*, Leemor Joshua-Tor. "Strategies for protein coexpression in Escherichia coli." Nature Methods (2006) Jan; 3(1):55-64
* corresponding author

Fabiola V Rivas#, #, Ji-Joon Song#, Juan P Aragon, Jidong Liu, Gregory J Hannon, Leemor Joshua-Tor. "Purified Argonaute2 and an siRNA form recombinant human RISC." Nature Structural & Molecular Biology (2005) Apr; 12(4):340-9. Epub Mar 30.

Ji-Joon Song, Jidong Liu, , Jonathan Schneiderman, Stephanie K Smith, Robert A Martienssen, Gregory J Hannon, Leemor Joshua-Tor. "The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes." Nature Structural Biology (2003) Dec; 10(12):1026-32. Epub Nov 16.